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As with fetal glucocorticoids, postnatal glucocorticoids or stress can alter synaptic pruning and can also lead to reduced GR expression in brain regions important for glucocorticoid negative feedback, the hypothalamus and hippocampus ( These effects of the perinatal environment on GR can be imposed long-term via changes to the epigenome

While copper peptides broadly reference several compounds, GHK-Cu is the specific, most-researched variant with an established safety and efficacy profile in scientific literature

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McKay DL, Blumberg JB: The role of tea in human health: an update